LOCAL IMMUNOPROTECTIVE MECHANISMS OF MICROCIRCULATION IN BLEEDING GASTRODUODENAL ULCERS

Abstract

Clinical research was conducted on 173 patients diagnosed with gastroduodenal ulcer. Patients were divided into 2 groups accordingly. Group I (comparison group) consisted of 42 patients with gastric and duodenal ulcers not complicated by bleeding, group II (main) – 131 patients with gastric and duodenal ulcers complicated by acute bleeding, and a control group of 36 volunteers without somatic pathology.
The study results showed that the intensity of formation of abnormal thrombo-leukocyte aggregates (TLA) in the peripheral blood in patients with "gastroduodenal ulcer complicated by bleeding" increases sharply, causing deterioration of the rheological-thrombogenetic properties of bleeding-peripheral blood.
In patients with "gastroduodenal ulcer complicated by bleeding", the severe, irreversible changes of the microcirculation network of the ulcer bottom, peri-ulcerative and relative-remote areas are directly proportional to "active gastroduodenal bleeding of ulcer origin".
Bleeding complication of gastroduodenal ulcer is directly (directly proportional) with the increase in the density of CD25-positive cells in the gastroduodenal mucosa and submucosa. At the same time, the increase level of CD25-positive cells around small vessels correlates proportionally with the bleeding factor.